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The reason I
take this is that the brain, especially an active one, produces high levels of
free radicals. These free radicals attack the fatty membranes of neurons,
which causes a premature loss of function. Also, acetylcholine, a critical
neurotransmitter, tends to fall off the cliff as we age. This devastating
cognitive decline steals your zest for life. When mental stress increases,
your joy of living decreases. This is why I take Cognitex.
-Peter
Protecting brain health is vital if
the pursuit of a longer life is to have any meaning. According to current
wisdom, some degree of cognitive impairment is all but inevitable as we
age.1-6 That is,
unless steps are taken to prevent it.7-12
The ideal strategy for preserving brain
function begins with preventing factors that may contribute to cognitive
decline. Good nutrition—including dietary supplements— and a healthy lifestyle
are key. As a first step toward ensuring brain health, keep your blood pressure
and weight in check. However, there is much more that can and should be done to
protect the aging brain. Nutritional support for the aging brain is of paramount
importance.
A powerful blend of nutrients
Cognitex is formulated to take advantage of the latest developments
and ingredients for cognitive health. The latest ingredient in the Cognitex
formula is uridine-5’-monophosphate, a critical brain nutrient.
Uridine-5’-monophosphate (UMP) is a
basic building block of RNA and DNA as well as of phosphatides such as
phosphatidylcholine that are critical to optimal brain function and the health
of neuronal cell membranes.* Naturally found in the milk of nursing mothers, UMP
is essential not only for the growth and development of infant brains, but also
for healthy cognitive function in aging adults.13 Dietary supplementation with UMP may
increase brain acetylcholine and phosphatide levels, and enhance some
cholinergic functions.14
The Cognitex formula provides other critical
extracts that support healthy brain function, such as blueberry standardized
with both anthocyanins and pterostilbene.*
Blueberry anthocyanins are
considered one of nature’s most potent antioxidants and have demonstrated
properties that extend well beyond suppressing free radicals. Pterostilbene,
the other blueberry constituent, helps maintain healthy lipid and glucose
levels in those already within normal range.8* Importantly, through their unique
biological effects; pterostilbene and anthocyanins may help
support DNA structure.9*
A crucial building block in the brain is
phosphatidylserine (PS). In fact, brain tissues are especially rich in this
nutrient, but aging causes a decline in the PS content of cells throughout the
body, which can lead to cognitive decline.* Phosphatidylserine
helps the brain use its fuel efficiently. By boosting glucose
metabolism and stimulating production of acetylcholine,
supplemental phosphatidylserine has been shown to improve the
condition of patients experiencing age-associated memory
impairment or cognitive decline.10,11* Thus, replacing this brain
food is essential.
Life Extension’s Cognitex formulas
contain a compound that mimics the naturally occurring PS in the brain. SharpPS
Gold™ fortified with omega-3 fatty acids delivers PS to the brain to help retard
the cognitive degeneration so often seen with advanced age.* These unique
nutrients have been extensively studied and may be of tremendous benefit for the
aging brain.12
More protection against free
radicals
The brain is a highly active organ that produces high
levels of free radicals. These free radicals can bombard the fatty membranes of
neurons and other brain cells causing premature loss of function. Cognitex
contains a number of phytonutrient-based antioxidants that work best in a lipid
(fat) rich environment like the brain.
While antioxidant nutrients provide
essential free radical protection, many have limited capacity once they have
spared an electron to balance a free radical. Cognitex contains a novel rosemary
extract that is rich in carnosic acid, which provides multi-step protection
against free radicals in a process called the carnosic acid cascade.15 At each step of free
radical interaction a new compound is formed, which in turn is a powerful
antioxidant in itself.
Bioavailable to the
brain
Nutritional support for the brain is challenging as a barrier
called the blood-brain barrier keeps out toxins as well as beneficial nutrients
and drugs. Cognitex contains a grape seed extract called Leucoselect®
Phytosome™. By pairing proanthocyanidins from grape seed extract with
phosphatides from soy lecithin in the Phytosome™, the uptake and distribution to
target tissues of the grape seed polyphenols is enhanced.
Once in the brain, the grape seed
polyphenols trap dangerous hydroxyl free radicals that turn fat rancid. These
fats make up the outer lipid membrane of trillions of brain cells. These
polyphenols also protect blood circulation and oxygen flow by improving the tone
and elasticity of blood vessels.*
Molecular size
matters
High levels of procyanidins from grape seed extract do not
ensure an extract is going to have a beneficial effect on the brain. Polyphenols
with higher molecular weight cannot be absorbed. Leucoselect® Phytosome™
contains smaller size molecules for advanced neurological
activity.
A difference you can
feel
Taking dietary supplements can often be an act of faith as we
often cannot feel what they are doing. Cognitex provides the patented,
nonstimulant phytonutrient called Sensoril®. Sensoril® is a proprietary
standardized extract of ashwagandha, also known as “Indian ginseng,” and used in
Ayurvedic traditional medicine for boosting brain function and alleviating
mental fatigue. Advanced extraction practices allow for a highly concentrated
yet balanced brain nutrient. The effects can often be felt immediately with
greater alertness and focus but without jitteriness.
Sensoril® also helps modulate the stress
response resulting in cortisol excretion. Stress can be very damaging to the
brain, especially memory function, and cortisol stimulates the body to release
sugar (glucose) into the bloodstream.
Advanced inflammation
protection
Cognitex provides a NeuroProtection Complex consisting of
highly concentrated standardized extracts of hops, ginger, and rosemary that
help suppress inflammatory cytokines.
Circulation Is key to
cognitive health
Brain cells such as neurons are fed by blood
vessels. Some of these microcapillaries can be so small that red blood cells
carrying oxygen have difficulty passing through them.
Neurons are the key structure for cognitive
functions including memory. Vinpocetine enhances blood flow by dilating blood
vessels and reducing blood viscosity. Vinpocetine enhances cerebral metabolism
by helping to maintain healthy blood flow and glucose levels in those already
within normal range, which enhances oxygen utilization.16*
Additional advanced brain
nutrients
L-alpha glycerylphosphorylcholine (A-GPC), an
acetylcholine precursor, is naturally present in all the body’s cells. Its
importance to life and safety as a supplement are evidenced by its substantial
presence in human breast milk.17,18 Acetylcholine is an essential neurotransmitter
involved in muscle control, sleep, and cognition. Alpha-GPC plays a key role in
both the synthesis and the catabolic recycling of phospholipids. Alpha-GPC
supplementation may result in an increased rate of phospholipid synthesis,
including the phosphoinositides available for signal transduction at central
nervous system level.19
Acetylcholine decline coincides
with advancing age, and is a hallmark of neurodegenerative decline. Cognitex
provides A-GPC as a crucial building block for the production of acetylcholine
in the brain.20,21
Cognitex is available with
pregnenolone. Concentrations of this critical hormone are much higher in the
brain, and studies show that this hormone has numerous mental benefits. All
these ingredients work synergistically to promote optimal cognitex
function. | 
